Thanks.
Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases
Edited by LUC MONTAGNIER Centre National de la Recherche Scientifique Institut Pasteur Paris, France RENE OLIVIER Institut Pasteur Paris, France CATHERINE PASQUIER Centre National de la Recherche Scientifique Faculte Xavier-Bichat INSERM U294 Paris, France(DR. LUC MONTAGNIER is the co-discoverer of the AIDS VIRUS)
Chapter 42
Nutriceutical Modulation of Glutathione with a Humanized Native Milk Serum Protein Isolate, Immunocal®: Application in AIDS and CancerSylvain Baruchel and Ginette Viau
McGill University-Montreal Children's Hospital Research Institute, Montreal, Quebec, Canada.
Rene Olivier
Pasteur, Institute Paris, France
Gustavo Bounous
Montreal General Hospital, Montreal, Quebec, Canada
Mark A. Wainberg
Jewish General Hospital, Lady Davis Institute, Montreal, Quebec, Canada
Abstract:
------------------------------------------- Treatment Models from India
Nutriceutical Modulation Of Glutathione With A Humanized Native Milk Serum Protein Isolate, Immunocal®: Application In AIDS And Cancer. S. Baruchel, G. Viau, R. Olivier, G. Bounous, M.A. Wainberg [Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases V Luc Montagnier et al., (Ed.) Marcel Dekker Inc., New York: 447-461, 1998 . ABSTRACT V] The biological activity of the proteins isolated from cow's milk in Immunocal® depends on the preservation of those labile proteins which share with the predominant human milk proteins the same extremely rare glutathione (GSH)-promoting components. This newly discovered nutriceutical modulation of GSH by the use of humanized native milk serum protein isolate of bovine origin in AIDS and cancer may well find other applications in disease where oxidative stress and pathology of GSH metabolism are largely implicated. In a pilot study, this type of whey protein concentrate was found to be well tolerated in children with AIDS and wasting syndrome and was found associated with an improvement of the nutritional status of the patient. Moreover, the GSH promoting activity on the peripheral blood lymphocyte of this protein concentrate was validated in patients with initial low GSH levels.
Interview with Shashank Joshi, M.D. By John S. James March 17, 2000 Shashank R. Joshi, M.D., president of the HOPE Foundation in Mumbai, India, is an HIV specialist in a public hospital system with more than 36,000 patients with HIV; in addition, he follows over 500 HIV patients in his private practice, and more than 180 HIV-discordant couples.
We asked Dr. Joshi to share information and experiences that might be useful to physicians or patients elsewhere.
An Evolving Standard of Care in India AIDS Treatment News:
How to you approach HIV care in India, where few patients have access to triple-drug combination antiretroviral treatment?
We are planning to study the product ImmunoCal, a nutritional supplement derived from whey protein, as a source of glutathione.
It is believed that mitochondrial toxicity, which the nucleoside analog drugs and hydroxyurea may have, is mediated through the glutathione pathway.
If you give patients a natural source of glutathione, maybe this problem can be prevented, and you may not see the liver toxicity, lactic acidosis, or other problems which might otherwise occur.
Learn More at TheBody.com --------------------------------- N-Acetylcysteine Boosts T-Cell Function in HIV-Infected Patients
By Eliza BusseyBETHESDA, MD, Apr 27 (Reuters Health)
Administration of N-acetylcysteine (NAC) to replenish glutathione (GSA) deficiency, improves T-cell function and blocks HIV expression in vitro. The finding was reported by Dr. Leonard A. Herzenberg of Stanford University Medical School in Stanford, California, at the Alcohol Use and HIV Pharmacotherapy conference held at the NIH on Thursday.Glutathione (GSH) deficiency impairs key T-cell functions and promotes cytokine-stimulated HIV expression, and is common among HIV-infected individuals with CD4 T-cell counts below 200 cells per microliter. Before highly active antiretroviral therapy (HAART), GSH deficiency in HIV patients was associated with markedly lower probability of surviving 2 to 3 years, Dr. Herzenberg explained.
During a placebo-controlled trial, Dr. Herzenberg and his colleagues also found that plasma levels of thioredoxin (Trx), a redox-active protein central to cell physiology, were elevated in HIV-infected people and predicted a poor survival rate in a 15-month period for patients with CD4 T-cell counts below 200 cells per microliter.
"Since oxidized stress increases Trx, we can see why it would normally be considered a death warrant," Dr. Herzenberg explained. "NAC blocks Trx release in vitro, and it is important because elevated Trx in immunodeficient individuals removes the last remaining barrier to establishment of opportunistic and other lethal infections."
"We would like to see these studies repeated with NAC as an adjuvant to HAART," Dr. Herzenberg. "It is important because HAART therapy only goes after the virus, while NAC helps restore the immune system.
Comment: N-acetyl cysteine is one of the dietary supplements that those HIV(+) people in the know have been taking for a dozen or more years. If there is one survival tool every HIV(+) person should consider it is taking dietary supplements that increase glutathione production. Suggested dosing is 500 to 1,000 mg three times per day.
Other supplements that increase glutathione include L-glutamine (12 to 36 grams per day), alpha lipoic acid (100 to 1,000 mg per day), selenium (200 - 800 mcg per day), and Immunocal whey protein (don't assume that other whey proteins have as much effect as Immunocal.)
Protein malnutrition can cause a decrease in glutathione production too, so be sure to get plenty of protein three times per day.
We provide more discussion of glutathione in our book Built To Survive, available by calling (800) 350-2392 or you can order it from www.Amazon.com by clicking here.
---------------------------------HOW TO INCREASE L-GLUTATHIONE LEVELS (Designer Protein or raw milk)
from POZ Magazine
For several years, research efforts focused on the use of one amino acid, N-Actyl-Cysteine (NAC), to increase Glutathione (GSH) levels in the cells. When some benefits in increased GSH levels were observed, higher doses were tried and they failed to work. Research shows that the immune system does not like high levels of NAC and produces antibodies against NAC (AIDSLINE). When the immune system attacks NAC or any other drug placed in your body, it is a waste of energy that could be better directed against viruses.
When B cell function finally fails completely, the job of removing toxic substances is left solely to the liver, the poor liver. Recently, a PWA from Chicago died from liver failure who was using the protease inhibitor/nucleoside drug cocktails along with several other drugs as a prophylasis. The liver failure is being blamed on the drug cocktail combo. There are better choices than fragmented approaches. Balanced medicine is complete and whole. For long term effectiveness, conditions like AIDS, CFIDS and cancer are too complex to simply treat with one drug or medicine. Fragmented medicine is a flash in the pan. Anti-viral treatment without immune modulation is another flash in the pan. As soon as viral resistance develops, its off to another drug cocktail combination.
It is a given fact that Glutathione(GSH) levels in persons with AIDS is severely depressed. Research shows that a cold processed whey product called Immunocal increases GSH levels in PWAs and increases muscle mass from 1 to 3 lbs per month(1). The component in whole raw milk that may increase GSH levels is gamma-glutamycysteine (1). The problem with pasteurized milk is damage is that the heat causes protein cross-linking and renders the glutamycysteine biologically useless. Designer Protein (Next Nutrition), like Immunocal, is cold processed and membrane filtered to remove any harmful bacteria.Whey protein (cold processed) and made derived from whole raw milk is one of nature’s richest sources of glutamycysteine. In a 3 month study with Immunocal, 3 HIV+ patients had a weight gain of 4.4 lbs to 15.4 lbs(1). Two returned to normal weight. Over a 3 month period, Glutathione levels increased in all 3 patients(1). The dose was increased form 8 grams to 39.2 grams daily. The products are lactose free. Presently, Designer Protein has 3 times more whey peptides than previous batches. Whey peptides increases the absorption for all nutrients by increasing receptor sites in the gastro-intestinal tract. This makes is it a far superior product than regular whey.
Because it is cold processed, Designer Protein is a far better product for improving immune function than any cooked protein where the application of heat produces protein cross-linking. Of all the protein supplements sold in health food stores, the only one I know of that is cold processed is Designer Protein and this is the only product I recommend for persons with AIDS, CFIDS or other conditions of immune dysfunction. 30 to 40 grams daily (about 2 scoops) are recommended to increase Glutathione levels. Because it improves absorption of all types of nutrients, Designer Protein or raw milk is expected to help restore Delayed Cutaneous Hypersensitivity (DCH) responses, a strong indicator of improved immune response. Glutathione levels can be increaed with NAC supplementation.
------------------------------------
Suggestion: If you use NAC, use 500 mg daily and take it with raw milk or Designer Protein.
1. Clin. Invest Med., Vol 16:3 pp. 204-209, by Gustavo Bounous et al of. Montreal Gen Hosp. Quebec.
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